Absolute Gene-ius
by Jordan Ruggieri, Lisa Crawford
Latest episode
Where qPCR shines – matching the right PCR technology to the…
Where qPCR shines – matching the right PCR technology to the…
About this podcast
The Applied Biosystems™ Absolute Gene-ius podcast is a fun and informative dive into the molecular methods behind modern biology. Each episode brings scientists and experts together for lively conversations about the technologies, workflows, discoveries, and career stories shaping life science research.
Episodes
The newest 20 of 51 episodes
- Where qPCR shines – matching the right PCR technology to the experiment · 15 min · Season 4 Episode 19While it’s been around for decades, that does not make qPCR outdated. In this Science Snapshot episode, past Absolute Gene-ius guests explain why real-time PCR remains a powerful…
- From biomarker discovery to monitoring – molecular tools for precision oncology · 34 min · Season 4 Episode 18Dr. Javier Hernández Losa of Vall d’Hebron University Hospital joins Absolute Gene-ius to discuss how biomarkers are shaping precision oncology and how researchers choose among…
- When the signal is barely there – strategies for rare target detection · 19 min · Season 4 Episode 17Rare genomic targets can carry important biological information, but finding and measuring them can be challenging when they are present at very low abundance or buried in…
- When qPCR says negative – finding IBV with digital PCR · 34 min · Season 4 Episode 16University of Calgary researcher Fathima Ishara Isham joins the Absolute Gene-ius hosts to explore infectious bronchitis virus (IBV), a coronavirus that affects poultry health…
- Better together – how qPCR and dPCR complement each other · 21 min · Season 4 Episode 15Are qPCR and digital PCR competing technologies or complementary tools? In this Science Snapshot, we revisit conversations with researchers across multiple disciplines to explore…
- Multiplexing qPCR without multiplying the complexity · 39 min · Season 4 Episode 14Thermo Fisher Scientific field application scientist Dr. John Pfeifer explains the fundamental differences between PCR, real-time PCR, and digital PCR, including when each…
- Beyond the band – understanding copy number variation · 20 min · Season 4 Episode 13Copy number variation (CNV) is one of the most important, and often overlooked, measurements in molecular biology. In this Science Snapshot, we revisit expert conversations to…
- qPCR, nested PCR, and the search for bacterial serotypes · 33 min · Season 4 Episode 12Donna Paznar joins Absolute Gene-ius to discuss her research on Streptococcus pneumoniae, including how children can serve as hidden reservoirs and why serotype tracking matters…
- How PCR, CRISPR, and animal models are advancing oncology research · 16 min · Season 4 Episode 11This Science Snapshot episode highlights oncology research-related conversations from past Absolute Gene-ius interviews, featuring expert insights on CAR-T research…
- Genotoxicity, vectors, and the power of integration site analysis · 35 min · Season 4 Episode 10Integration site analysis is becoming a critical tool in evaluating the safety of gene therapies, but how does it actually work, and when does it matter most? Michael Stump and…
- From brewing to bioprocessing – Steve Lewis on molecular biology trends · 23 min · Season 4 Episode 9In this crossover episode, Absolute Gene-ius welcomes Steve Lewis, host of Speaking of Mol Bio and Director of Product Management at Thermo Fisher Scientific, for a wide-ranging…
- Epigenetics unlocked – how behavior shapes biology · 42 min · Season 4 Episode 8Epigenetics reveals how environment and behavior shape gene expression without altering DNA. In this episode, Dr. Robert Philibert explores how these changes drive disease and…
- Multiplexing in action – from simplicity to scientific complexity · 19 min · Season 4 Episode 7PCR multiplexing enables scientists to measure multiple DNA or RNA targets in a single reaction, unlocking more insight from limited samples. This episode revisits real-world…
- Finding the cheat codes to cell identity · 33 min · Season 4 Episode 6Fiona Connolly, formerly with bit.bio, joins Absolute Gene-ius to explore how deterministic programming of induced pluripotent stem cells (iPSCs) is transforming disease modeling…
- Science happens, and so do mistakes · 14 min · Season 4 Episode 5Every scientist has a lab fail they’ll never forget. In this Science Snapshot “best of” episode, Absolute Gene-ius revisits unforgettable lab mishaps recounted by past guests…
- Almost a virus – how AAV powers modern gene therapy · 33 min · Season 4 Episode 4In this episode, the hosts sit down with Dr. Dan Mitchell of Matica Biotechnology to explore how viral vectors are engineered, analyzed, and manufactured for cell and gene…
- How sequencing and PCR work together in oncology research · 33 min · Season 4 Episode 3Dr. Kathie Sollweck, Senior Medical Affairs Manager for Oncology at Thermo Fisher Scientific, joins the Absolute Gene-ius team to explore how liquid biopsy, sequencing, and PCR…
- When PCR gets dirty - tackling PCR inhibitors · 12 min · Season 4 Episode 2PCR inhibitors are a hidden but pervasive challenge across environmental testing, wastewater surveillance, and gene therapy workflows. In this first Science Snapshot episode, the…
- Tracking grape pathogens from air to vine · 36 min · Season 4 Episode 1In this season-opening episode of Absolute Gene-ius, hosts Jordan Ruggieri and Lisa Crawford talk with Lexi Heger, PhD candidate at Michigan State University, about applying qPCR…
- Season 4 – new voices, new discoveries · 6 min · Season 4The Absolute Gene-ius podcast series is back for Season 4 with a fresh co-host, new guests, and an even broader lens on molecular biology. Get a behind-the-scenes look at what’s…
