Hard Drugs
von Saloni Dattani & Jacob Trefethen
Neueste Folge
Can we switch off diseases?
Can we switch off diseases?
Über diesen Podcast
Hard Drugs is a show by Saloni Dattani and Jacob Trefethen about medical innovation: how to speed it up, how to scale it up, and how to make sure lifesaving tools reach the people who need them the most. It is brought to you by Works in Progress.
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- Can we switch off diseases? · 1 Std. 15 Min. · Folge 12What if treating diseases was as simple as telling your cells to stop making a harmful protein? That’s the premise of siRNA, a technology that silences genes without changing…
- Are miracle drugs hiding in plain sight? · 2 Std. 31 Min. · Folge 11GLP-1 drugs like Ozempic and Mounjaro have transformed the treatment of obesity as well as diabetes, help treat heart disease, kidney disease, sleep apnea, and maybe even…
- Inventing the second malaria vaccine with Katharine Collins · 2 Std. 15 Min. · Folge 10Malaria is caused not by a virus or bacterium, but by a complex, shape-shifting parasite that has evolved alongside us for millennia. This has made vaccine development a brutal…
- Should everyone be taking statins? · 2 Std. 54 Min. · Folge 9Heart disease is the leading cause of death worldwide, but it’s also one of medicine’s biggest success stories. Since the 1950s, the risk of dying from cardiovascular disease has…
- The first cancer vaccine · 2 Std. 58 Min. · Folge 8Hepatitis B is a tiny virus that causes hundreds of thousands of deaths from liver disease and cancer each year. The vaccine against it became the first of many milestones: it…
- The history of vaccines · 2 Std. 6 Min. · Folge 7Before vaccines became routine, they were risky experiments. In this episode, Jacob and Saloni travel back to the world of smallpox, cowpox, and cow-based “vaccine farms” to see…
- Will AI solve medicine? · 4 Std. 34 Min. · Folge 6Artificial intelligence is transforming how we discover and develop new medicines. But how far can it really take us? In this episode, Jacob and Saloni trace the path of drug…
- The art of protein design with AI · 1 Std. 0 Min. · Folge 5What if you could design a protein never seen in nature? In this episode, Jacob and Saloni explore how researchers are using new tools like RFDiffusion, AlphaFold, and…
- Hacking proteins with AI · 55 Min. · Folge 4Nature didn’t evolve all the proteins we need, but maybe artificial intelligence can help. Jacob and Saloni explore how tools like AlphaFold and ProteinMPNN are helping…
- 100 years of insulin in 15 minutes · 18 Min. · Folge 3A hundred years ago, insulin was scraped from pig pancreases. Today, it’s made by bacteria in giant tanks. In the second part of a mini series on proteins, drug development and…
- Proteins: Weird blobs that do important things · 20 Min. · Folge 2This episode kicks off a mini-series on proteins, drug development and AI. Saloni and Jacob explore the world of proteins, including how proteins fold into complex shapes, why…
- Lenacapavir: The miracle drug that could end AIDS · 4 Std. 53 Min. · Folge 1Lenacapavir is a new HIV drug that blocks infections with an efficacy rate of nearly 100%, and it could completely change the fight against HIV worldwide. Saloni and Jacob talk…
- Coming soon: Hard Drugs · 1 Min. · Folge 1Hard Drugs is a new podcast about medical innovation: how to speed it up, how to scale it up, and how to make sure lifesaving tools reach the people who need them the most…
