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Discuss Diabetes and Endocrinology studies in a simplified manner. Expand your knowledge in Diabetes and Endocrinology.
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- Romosozumab 3 vs 12: 3 months of romosozumab | Hormone Insight Podcast · 4 minIs 3 months of romosozumab noninferior to 12 months for increasing hip BMD in postmenopausal osteoporosis? In postmenopausal women at high fracture risk, 3 months of romosozumab…
- CHIRACIC: Surgery for mild cortisol excess? | Hormone Insight Podcast · 4 minCan surgery treat arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion? In patients with hypertension and mild…
- TRAVERSE: Is testosterone heart-safe? | Hormone Insight Podcast · 4 minWas testosterone replacement non-inferior to placebo for cardiovascular safety in men with hypogonadism and high cardiovascular risk? In TRAVERSE, testosterone replacement was…
- Statin side effects: Which ones are real? | Hormone Insight Podcast · 4 minWhich statin side effects are supported by blinded trials? Blinded-trial evidence supported increased liver-test abnormalities but did not show excess risk for most other…
- CLEAR Outcomes: Statin-intolerant patients | Hormone Insight Podcast · 4 minDoes bempedoic acid reduce cardiovascular events in statin-intolerant patients? In CLEAR Outcomes, bempedoic acid lowered LDL cholesterol and reduced major adverse…
- LT4 withdrawal: Can we stop levothyroxine? | Hormone Insight Podcast · 4 minCan levothyroxine be discontinued in older adults with subclinical hypothyroidism? In a pilot randomised trial, stopping low-dose levothyroxine did not change hypothyroid…
- ORBIT: IL-17 for thyroid eye disease? | Hormone Insight Podcast · 4 minIs secukinumab effective for active, moderate-to-severe Graves orbitopathy? In a randomised trial, secukinumab did not improve clinical response compared with placebo at 16…
- GRASS: Selenium in Graves' | Hormone Insight Podcast · 4 minDoes selenium supplementation benefit people with newly diagnosed Graves' hyperthyroidism? In the GRASS randomised trial, selenium did not improve remission rates or quality of…
- ESTIMABL2: No radioiodine at 5 years | Hormone Insight Podcast · 4 minWhat happens at 5 years of follow-up with thyroidectomy without radioiodine in patients with low-risk thyroid cancer? In patients with low-risk differentiated thyroid cancer, a…
- IoN: Skip radioiodine? | Hormone Insight Podcast · 4 minAfter thyroidectomy for low-risk differentiated thyroid cancer, is omission of postoperative radioiodine non-inferior to ablation? In the IoN randomised trial, omission of…
- Rosiglitazone: A heart attack signal? | Hormone Insight Podcast · 4 minDoes rosiglitazone increase myocardial infarction or cardiovascular-death risk in type 2 diabetes? A 2007 meta-analysis found a higher risk of myocardial infarction than…
- Closed-loop under 7: Automated insulin delivery | Hormone Insight Podcast · 4 minDoes automated insulin delivery improve glucose control in children under 7 with type 1 diabetes? A 2026 meta-analysis reported improved time in range and HbA1c compared with…
- GRADE: Fewer admissions? Not so fast | Hormone Insight Podcast · 4 minDoes liraglutide reduce hospitalization risk compared with glimepiride in people with type 2 diabetes on metformin? In GRADE participants with type 2 diabetes on metformin, time…
- SURPASS-4: Tirzepatide and the kidney | Hormone Insight Podcast · 5 minDoes tirzepatide improve kidney outcomes compared with insulin glargine in type 2 diabetes with high cardiovascular risk? In people with type 2 diabetes and high cardiovascular…
- SOUL: Oral semaglutide and the heart | Hormone Insight Podcast · 4 minDoes oral semaglutide reduce major adverse cardiovascular events in high-risk type 2 diabetes patients? In people with type 2 diabetes and atherosclerotic cardiovascular…
- SELECT: Weight drug, heart benefit | Hormone Insight Podcast · 4 minDoes weekly subcutaneous semaglutide 2.4 milligrams reduce cardiovascular events in patients with obesity without diabetes? In patients with established cardiovascular disease…
- STEP TEENS: Semaglutide for teens | Hormone Insight Podcast · 4 minDoes once-weekly 2.4 milligram subcutaneous semaglutide plus lifestyle intervention reduce BMI more than lifestyle intervention alone in adolescents with obesity? In adolescents…
- ATTAIN-MAINTAIN: Keeping the weight off | Hormone Insight Podcast · 4 minCan oral orforglipron preserve weight loss after stopping tirzepatide or semaglutide? In selected adults without diabetes, switching to orforglipron preserved more of their…
- STEP-1: What happens when you stop? | Hormone Insight Podcast · 4 minDoes withdrawal of once-weekly subcutaneous semaglutide 2.4 milligrams lead to weight regain and reversal of cardiometabolic benefits in adults with obesity? In adults with…
- SURMOUNT-1: 20% weight loss | Hormone Insight Podcast · 4 minDoes once-weekly tirzepatide reduce body weight in adults with obesity? In adults with obesity, once-weekly tirzepatide reduced body weight substantially more than placebo over…
