In the Interim...
by Berry
Latest episode
Reflecting on EMA Reflections on Platform Trials
Reflecting on EMA Reflections on Platform Trials
About this podcast
A podcast on statistical science and clinical trials.
Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailored for pharma pioneers. Featuring expertise from industry leaders, each episode is crafted to provide clarity, foster debate, and challenge mainstream perspectives, ensuring you remain at the forefront of clinical trial excellence.
Episodes
The newest 20 of 83 episodes
- Reflecting on EMA Reflections on Platform Trials · 44 min · Episode 83In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele, Director of Research at Berry Consultants, review the European Medicines Agency's draft reflection paper…
- Statistical Methodology Groups in the Pharmaceutical Industry · 56 min · Episode 82In this episode of "In the Interim…", Scott Berry is joined by Jenny Devenport and Kaspar Rufibach of Merck Group, co-authors of the EFSPI Statistical Methodology Leaders paper…
- A Discussion on Virtual Controls · 47 min · Episode 81In this episode of "In the Interim…", Dr. Scott Berry shares the framework he presented at a CSRC regulatory science hackathon on digital twins and synthetic controls in…
- Clinical Trial Arenas: Direct Communication to Patients · 43 min · Episode 80In this episode of "In the Interim…", Dr. Scott Berry recounts a presentation he gave to the Speak Foundation, a patient organization focused on limb-girdle muscular dystrophy…
- Science Coaching With Alun Bedding · 45 min · Episode 79In this episode of "In the Interim…", Dr. Scott Berry talks with Dr. Alun Bedding, a professional certified coach and statistician who spent decades in pharmaceutical statistics…
- The CHIPS Trial: Bayesian Adaptive Trial in JAMA · 46 min · Episode 78In this episode of “In the Interim…,” Dr. Scott Berry talks with Dr. Roger Lewis, Dr. Anna McGlothlin, and Dr. Nick Berry — all co-authors on the CHIPS trial results recently…
- NFL Study of CTE: The Issues · 39 min · Episode 77In this episode of "In the Interim…", Dr. Scott Berry examines three recent health-research headlines through a statistician's lens: an Adventist Health Study-2 analysis claiming…
- Talkin' 'bout Sweet Time · 47 min · Episode 76In this episode of "In the Interim...", Dr. Scott Berry dissects prevailing concepts of “clinically meaningful difference” in clinical trials focusing on progressive diseases…
- Mammograms: Death Threats, Hillary Clinton and Lead-Time Bias · 1 h 5 min · Episode 75In this episode of "In the Interim…", Dr. Don Berry provides a detailed account of co-chairing the 1997 NIH consensus development conference on mammography for women in their…
- REMAP-CAP Results: Oseltamivir in Critically-Ill Influenza Patients · 52 min · Episode 74In this episode of "In the Interim…", Dr. Scott Berry speaks with Dr. Srinivas Murthy, Dr. Thomas Hills, and Dr. Lindsay Berry about the REMAP-CAP trial results on oseltamivir in…
- ICECAP: The Results · 55 min · Episode 73In this episode of "In the Interim…", Dr. Scott Berry leads a comprehensive discussion of the ICECAP trial results with four Principal Investigators: Dr. Will Meurer (Professor…
- Failure of the Proportional Odds is the Result · 40 min · Episode 72In this episode of "In the Interim…", Dr. Scott Berry and Dr. Elizabeth Lorenzi systematically examine the analytic pitfalls in recent acute ischemic stroke trials, especially…
- Adaptive Design Actions Matrix · 31 min · Episode 71In this episode of "In the Interim…", Dr. Scott Berry challenges the widely held belief that any interim look at trial data obligates an alpha adjustment. By constructing a…
- A Visit With Tim Berry · 44 min · Episode 70In this episode of "In the Interim…," Dr. Scott Berry interviews Tim Berry, co-founder of Blend360, detailing a career that demonstrates the practical application of statistical…
- Fairness in Soccer and Clinical Trials · 35 min · Episode 69In this episode of "In the Interim...", Dr. Scott Berry investigates the practical meaning of fairness by connecting a controversial World Cup soccer ruling to foundational…
- Bias in Stopping Trials Early · 39 min · Episode 68On the latest episode of "In the Interim...", Dr. Scott Berry and Dr. Kert Viele deliver a focused, technical analysis of statistical bias when stopping trials early. This…
- A Statistician Reads JAMA: A Futile Issue · 46 min · Episode 67On the latest episode of "In the Interim…", Dr. Scott Berry provides an empirical examination of two recent JAMA trials: TRACK (low-dose rivaroxaban in advanced kidney disease)…
- Response-Adaptive Randomization in Clinical Trials · 47 min · Episode 66In this episode of "In the Interim…", Dr. Scott Berry and Dr. Kert Viele examine response-adaptive randomization (RAR) in clinical trials, dissecting its statistical rationale…
- REMAP-CAP: The Origin · 53 min · Episode 65In this episode of "In the Interim…", Dr. Scott Berry explores the origins of REMAP-CAP with Prof. Steve Webb, former chair of the REMAP-CAP International Trial Steering…
- Fighting Time in Adaptive Trials · 56 min · Episode 64In this episode of "In the Interim…", Dr. Scott Berry explores the challenge of protracted endpoint timelines in adaptive clinical trials and the statistical strategies used to…
