About this podcast
Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who's who in genomics and genomic medicine.
www.mendelspod.com
Episodes
The newest 50 of 582 episodes
- The $60 Genome, Virtual Cell Modeling and the Future of Biology, with Gilad Almogy, Ultima Genomics · 6 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com Can we scale our way to a better understanding of biology? When we first had the CEO and founder…
- Precision Oncology 2.0: From Tumor Profiling to Continuous Monitoring with Jerry Radich, Fred Hutch · 24 minPrecision oncology is entering a new phase. Rather than simply profiling a tumor and matching it to a drug, physicians are increasingly able to follow a patient’s cancer over…
- The UK’s Next Big Bet on Precision Medicine: Our Future Health with CEO Raghib Ali · 39 minIn the US, we have the All of Us Research Program. In the UK, they have Our Future Health, an ambitious new population health research program that aims to make healthcare more…
- From the Archives: The Dark Genome Is Coming Into Focus with Sudhakaran Prabakaran · 37 minIn recent months on Mendelspod, we’ve explored how new sequencing and proteomics technologies are revealing biology in regions of the genome (and proteome) that have long escaped…
- Repeat Expansions and the Promise of Long Reads with Alex Lindell and Simon Sadedin · 32 minRepeat expansions are places where the genome has remained stubbornly dark. Long-read sequencing is beginning to illuminate them, and now that new visibility is moving into…
- How Roswell Park Is Rethinking Molecular Testing for Blood Cancers with Sean Glenn · 19 minSometimes the best evidence that a new medical technology is working is simply that doctors start depending on it. For years, the promise of molecular medicine has been that…
- Building a Single Cell Atlas of the Poplar Tree with Robin Buell and Anita Giabardo · 25 minPlant biology too is benefiting from single cell resolution. Unlike animals, plants cannot move away from environmental stress. They have evolved tremendous biological complexity…
- Three Illumina 5-Base Grant Contest Winners Share Cancer Research Insights from Combining Epigenetics and Genetics · 29 minWhat new insights can we learn about cancer when researchers are able to look at the genome and the methylome together? Recently, Illumina launched its 5-base for Cancer Research…
- Ten Years Ago Mike Joyner Was Skeptical of Precision Medicine. What Does He Say Today? · 6 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com A recent New York Times article highlighted a remarkable study showing that exercise can help…
- Deeper into the Genome: Google DeepMind’s Ziga Avsec on the New AlphaGenome Atlas · 5 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com Is biology headed back into the genome? While much of biology has been expanding outward into…
- Mass Spec Comes to the Routine Core Lab: Don Mason of Roche on a New Era in Clinical Testing · 23 minMass spectrometry has been one of the most powerful technologies in clinical testing for decades. So why is it still largely confined to specialty labs? Don Mason has spent more…
- Jennifer Dionne Wants to Read the Whole Proteome Using Nanophotonics, i.e. Raman Spectroscopy · 6 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com Jennifer Dionne, Stanford physicist and co-founder of Pumpkinseed, joins us to talk about a…
- Katie Maloney, Partner at DeciBio Consulting, Sees an Inflection Point for Digital and Computational Pathology · 6 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com Digital technology has been promising to transform pathology for years. But the last year looks…
- It’s One of the Greatest Success Stories of Molecular Medicine. Genomics Historian Kevin Davies on His Latest Book about Casgevy and Sickle Cell Disease · 6 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com It was the heady days of the CRISPR revolution and of the gene therapy Casgevy. And when…
- Elias Sayour on the Cancer Vaccine Breakthrough · 6 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com After being pursued for more than 150 years, cancer vaccines may finally be having their moment…
- What Single Cell Sequencing Revealed About Pulmonary Fibrosis with Nick Banovich, TGen · 37 minSingle cell sequencing has given researchers extraordinary new maps of human biology. For Nick Banovich of TGen, the burning question is how to turn those maps into something…
- The Quest to Measure Protein Function with Polly Fordyce, Stanford · 32 minStanford physicist and bioengineer Polly Fordyce has a big vision. She’s attempting to measure protein function at the scale at which we learned to measure DNA. We can sequence…
- Doubling Down on Long Reads: New CEO of PacBio, Mark Van Oene · 31 minMark Van Oene has just taken over as CEO of Pacific Biosciences, and Mendelspod is his first interview in the new job. He began his career as a scientist studying cystic fibrosis…
- Serge Saxonov on What’s Next for 10x Genomics · 5 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com 10x Genomics has been remarkably good at figuring out where biology is going next. In this…
- “You Cannot Discover What You Cannot Make”: Lee Cronin on Programming Chemistry · 5 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com Those of us in biology tend to think that chemistry is rather straight forward. But today’s…
- All of Us Comes of Age. And So Does Its Funding: Josh Denny on the Next Phase of Precision Medicine · 47 minThere are very few genomics projects with the level of ambition of the NIH All of Us Research Program. The latest release includes data from more than 747,000 participants…
- Season Opener: Is Biology Having Its Newtonian Moment? with Rob Phillips, Caltech · 41 minWelcome to Mendelspod’s 16th season! It’s hard to believe we’ve been doing this for just over 15 years, following first and foremost the people reshaping biology and medicine…
- From the Archives: Erdinc Sezgin and the Physics of Living Cells · 33 minOn Mendelspod, we’re always searching for scientists who are looking at biology in new ways. Sometimes that means a new technology. Sometimes it means asking entirely different…
- From the Archives: How Cellanome Is Changing the Way We Study Cell Function with Matthew Spitzer and Pier Federico Gherardini · 24 minOne of the biggest technology shifts we saw in biology over the past year came from the young company, Cellanome. Instead of relying only on static single-cell snapshots, the…
- Agilent and Oxford Nanopore Discuss Bringing Long Reads to the Clinic with a Customer · 29 minAcute leukemia patients often wait days or even weeks for the full battery of molecular tests needed to guide treatment decisions. Dr. Parth Shah from Dartmouth believes long…
- Liquid Biopsy for the Tumor Microenvironment: with Vince Miller and Mirna Jarosz · 4 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com We’ve become remarkably good at reading cancer cells. Spatial biology enabled us to read them in…
- Can Liquid Biopsy Transform Chronic Disease? Hamed Amini and Soheil Damangir of Hepta · 5 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com For the past decade, liquid biopsy has largely been defined by oncology. Tumors shed DNA…
- The UAE’s Big Bet on Genomic Medicine with Mohamed Alameri and Albarah El-Khani · 46 minThe future of genomics has arrived in Abu Dhabi. On today’s show, Dr. Mohamed Alameri of the UAE Department of Health and Albarah El-Khani of M42 describe one of the most…
- Ryan Flynn of Harvard on Non-Coding RNA · 41 minOn today’s show, Dr. Ryan Flynn of Harvard Medical School and Boston Children’s Hospital takes us into a newly emerging layer of biology: the architecture of the cell surface…
- Gary Schroth on Connecting Cellular Behavior to the Transcriptome · 33 minFor decades, biology has been driven by the powerful notion that if we could sequence enough genomes, transcriptomes, epigenomes, then we could finally explain the cell. On…
- Two-Thirds of High-Risk Breast Cancer Patients May Avoid Chemotherapy According to Veracyte Data Presented at ASCO · 27 minToday on the show, we’re discussing a new study just presented at ASCO 2026 that could change how chemotherapy decisions are made for a large group of breast cancer patients…
- Building the Diagnostic Layer of Modern Cancer Care with Rita Shaknovich and Karina Kulangara of Agilent · 32 minFor years, precision oncology has largely been discussed through the lens of breakthrough drugs. But there’s another story running underneath modern cancer care: the quiet rise…
- Mapping the Multi-Omic Era with Eric Green of Illumina · 44 minDr. Eric Green returns to Mendelspod in a new role: Chief Medical Officer of Illumina. After more than three decades at the National Human Genome Research Institute, where he…
- Inside Proteomics at Thermo Fisher with Yan Zhang · 5 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com For years, proteomics was described as the missing layer of biology. Why missing? Because…
- Separating Epigenetic Signals Improves Early Cancer Detection with Rob Osborne, Biomodal · 23 minWe’ve gotten very good at reading DNA. We’re just beginning to understand how to read its state. On today’s show, Rob Osborne, Senior Vice President of R&D at Biomodal, discusses…
- Digital Controls for Cancer Drug Trials? Irina Babina, Concr · 4 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com On today’s show, a fascinating discussion about digital twins for medical research— leading to…
- Solexa Co-Inventor Shankar Balasubramanian on Six-Base Sequencing and What's Next in Genomics · 38 minAn inventor of Solexa sequencing by synthesis has a new idea. On today’s show, Sir Shankar Balasubramanian revisits the accidental origins of Solexa sequencing, born not from a…
- The Next Frontier in Biology: Physics? Erdinc Sezgin of the Karolinska Institute · 33 minThere’s a famous line attributed to Ernest Rutherford, the father of nuclear physics: “All science is either physics or stamp collecting.” It’s still provocative. But it’s unfair…
- The Case for a 6-Base Genome with Peter Fromen, CEO of Biomodal · 35 minYou’ve heard of 5-base genomics. How about 6-base? It turns out that separating 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) is pretty important. Peter Fromen has had…
- The Eligible But Under-Tested: Genomic Medicine in 2026 with Damon Hostin, Illumina · 40 minWhat is the value of someone’s genome over their life? Is a genome today what it was 10 years ago? How does the adoption of genomic testing compare to other areas in medicine…
- Spatial Transcriptomics Is Changing How We Do Biology: Fei Chen, The Broad Institute · 32 minFei Chen of the Broad Institute describes the original problem simply: genomics gave us powerful inventories of gene expression, while microscopy gave us structure—yet the two…
- Beyond GLP-1: Why Peptides Are Back at the Center of Drug Discovery with Charlie Johannes and Tomi Sawyer · 44 minPeptides are having a moment. But beneath the market excitement and the GLP-1 headlines, something more interesting is going on. A field that for years seemed technically…
- From the Archives: Inventor Mark Kokoris Debuts Roche’s New SBX Sequencer · 36 minIt was the biggest story in sequencing last year: Mark Kokoris, head of SBX sequencing at Roche and inventor of the technology, joins Mendelspod to talk about how Sequencing by…
- Why Do Some Animals Live Ten Times Longer? Pursuing the Science of Aging with Steve Austad · 38 minWhy do some animals live ten times longer than others? That question opens today’s interview with Steve Austad, Distinguished Professor at the University of Alabama at Birmingham…
- MRD Testing: From Residual Disease to Real Decisions with Chris Hourigan and Gary Pestano · 34 minMolecular residual disease, or MRD, has been part of oncology’s vocabulary for decades. But knowing something is there and being able to measure it precisely are two very…
- Early vs Late Recurrence: How Multimodal AI Is Changing Breast Cancer Prognosis with George Sledge, Caris Life Sciences · 4 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com For two decades, tests like Oncotype DX have helped oncologists decide which early-stage breast…
- The Dark Genome with Author Sudhakaran Prabakaran · 37 minWe began this podcast back around the time the ENCODE project announced that much of the genome was biochemically active. The big science project was undoing the tidy idea of…
- Illumina's New Mapped Read Technology Provides Insights into Rare Disease: Stephen Kingsmore, Olivia Kim-McManus and Ali Crawford · 27 min“We have been talking now for 15, 20 years about the diagnostic odyssey. That shouldn’t exist anymore. The new odyssey is the therapeutic odyssey.” That’s Stephen Kingsmore…
- CareDx’s Second Act with CEO John Hanna · 5 minThis is a free preview of a paid episode. To hear more, visit www.mendelspod.com CareDx is a company on the move. For years, they have been a bellwether in molecular…
- Inside GP2: Building a Global Genetic Map of Parkinson’s with Andrew Singleton and Ignacio Mata · 41 minLarge-scale genomics is back — and this time, it’s global by design. In this episode of Mendelspod, we return to the kind of ambitious, shared genomics project that helped define…
