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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderAnti-Aging Series: https://www.youtube.com/playlist?list=PLwiri7XRU2i-HLExt7W-5qp_z2tIP_UvU0:00 - Introduction0:55 - Senolytics: An Advanced Future3:44 - Bone, Kidneys, Liver, and…5:57 - Molecules and ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1093] Hickson LJ, Langhi Prata LGP, Bobart SA, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446–456. doi:10.1016/j.ebiom.2019.08.069.[Study 1094] Farr JN, Atkinson EJ, Achenbach SJ, et al. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nat Med. 2024;30:2605–2612. doi:10.1038/s41591-024-03096-2.[Study 1095] Justice JN, Nambiar AM, Tchkonia T, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554–563. doi:10.1016/j.ebiom.2018.12.052.[Study 1096] Martyanov V, Whitfield ML, Varga J. Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response? Arthritis Rheumatol. 2019;71(10):1766–1767. doi:10.1002/art.40934.[Study 1097] Hambright WS, Duke VR, Goff AD, et al. Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes. Aging Cell. 2024;23. doi:10.1111/acel.14113.[Study 1098] Gao X, Roder J, Minas LT, et al. Effects of two fisetin dosing regimens on reducing senescence-related genes in peripheral blood mononuclear cells in aged humans. Preprints. Published online July 22, 2026. doi:10.20944/preprints202607.1685.v1.[Study 1099] Koning M, Kovynev A, Fondevila MF, et al. Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial. Nat Metab. 2026. doi:10.1038/s42255-026-01643-4.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
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