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von Raymond Ruff
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Episode 97: Aberrant expression of HERV-K envelope in lymphoma…
Episode 97: Aberrant expression of HERV-K envelope in lymphoma…
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Ten-minute paper summaries for scientists and experts.
Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever's catching the research community's attention that week.
Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured scientific skepticism rather than hype.
Feedback and paper suggestions: [email protected]
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- Episode 97: Aberrant expression of HERV-K envelope in lymphoma represents an opportunity for novel treatments. · 11 Min. · Folge 97Monday Immune Engager — our weekly pick from the latest immune-engager digest. Aberrant expression of HERV-K envelope in lymphoma represents an opportunity for novel treatments…
- Episode 96: Reddit Trending — The dietary fibre content of fruit and vegetable kitchen preparation waste and UK consumers’ dietary fibre-related attitudes regarding its consumption · 11 Min. · Folge 96Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. The dietary fibre content of fruit and vegetable kitchen preparation waste and UK…
- Episode 95: Shared α-helix chimeraffibodies enable linker-free bispecific protein design · 11 Min. · Folge 95Monday Immune Engager — our weekly pick from the latest immune-engager digest. Shared α-helix chimeraffibodies enable linker-free bispecific protein design Cell Chemical…
- Episode 94: Reddit Trending — The Effect of Deactivating Facebook and Instagram on Users’ Emotional State · 10 Min. · Folge 94Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. The Effect of Deactivating Facebook and Instagram on Users’ Emotional State American…
- Episode 93: Reddit Trending — Associations of food processing and dietary risk factors with colorectal cancer incidence in the NIH-AARP Diet and Health Study: A cohort study · 11 Min. · Folge 93Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Associations of food processing and dietary risk factors with colorectal cancer incidence…
- Episode 92: Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism · 12 Min. · Folge 92Monday Immune Engager — our weekly pick from the latest immune-engager digest. Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism Nature, 2026 DOI…
- Episode 91: Reddit Trending — “It’s Like You’re Trying to Defuse a Bomb”: Fear, Responsibility, and Shame in Young Men’s Sexual Lives · 10 Min. · Folge 91Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. "It's Like You're Trying to Defuse a Bomb": Fear, Responsibility, and Shame in Young…
- Episode 90: Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition · 9 Min. · Folge 90Monday Immune Engager — our weekly pick from the latest immune-engager digest. Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition…
- Episode 89: Reddit Trending — Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse · 10 Min. · Folge 89Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the…
- Episode 88: GPCR antagonism via rewiring of receptor trafficking and degradation · 12 Min. · Folge 88Monday Immune Engager — our weekly pick from the latest immune-engager digest. GPCR antagonism via rewiring of receptor trafficking and degradation Nature, 2026 DOI…
- Episode 87: Reddit Trending — Did Donald Trump Receive a Mandate for Sweeping Change in 2024? · 11 Min. · Folge 87Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Did Donald Trump Receive a Mandate for Sweeping Change in 2024? PS: Political Science &…
- Episode 86: Specific targeting of MR1-antigen complexes using nanobodies · 11 Min. · Folge 86Monday Immune Engager — our weekly pick from the latest immune-engager digest. Specific targeting of MR1-antigen complexes using nanobodies Science Immunology, 2025 DOI…
- Episode 85: Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits · 11 Min. · Folge 85Monday Immune Engager — our weekly pick from the latest immune-engager digest. Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell…
- Episode 84: Reddit Trending — Predictors and prevalence of support for white nationalism in the United States · 11 Min. · Folge 84Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Predictors and prevalence of support for white nationalism in the United States Nature…
- Episode 83: Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex · 11 Min. · Folge 83Monday Immune Engager — our weekly pick from the latest immune-engager digest. Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex mAbs…
- Episode 82: Reddit Trending — Substantial under-detection of human rabies cases in the United States · 11 Min. · Folge 82Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Substantial under-detection of human rabies cases in the United States Communications…
- Episode 81: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability · 23 Min. · Folge 81Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental…
- Episode 80: Reddit Trending — Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata · 15 Min. · Folge 80Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Educational expansion and the hidden reversal of the Flynn effect—Differential…
- Episode 79: Reddit Trending — Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study · 22 Min. · Folge 79Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Probability of a timely vocal response in mother-infant interaction and later…
- Episode 78: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation · 22 Min. · Folge 78Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of…
