The Stem Cell Report with Janet Rossant
de ISSCR
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Two Decades of iPS Cells: Perspectives from the Field
Two Decades of iPS Cells: Perspectives from the Field
Sobre este podcast
Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Rossant goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.
Episódios
Os 20 episódios mais recentes de 52
- Two Decades of iPS Cells: Perspectives from the Field · 30 min · Temporada 5 Episódio 5In 2006, Kazutoshi Takahashi and Shinya Yamanaka at Kyoto University published their landmark paper showing that mouse skin cells could be reprogrammed to an embryonic-like state…
- Repair the Second Brain · 56 min · Temporada 5 Episódio 4The enteric nervous system (ENS) is an intricate network of neurons and glia lining the gastrointestinal tract, regulating digestion and overall health. Loss of ENS neurons, as…
- Born Without a Nose · 37 min · Temporada 5 Episódio 3Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests today…
- Therapeutic Strategy for COVID-19-Induced Acute Respiratory Distress Syndrome · 49 min · Temporada 5 Episódio 2Acute respiratory distress syndrome (ARDS) induced by COVID-19 was a leading cause of severe illness and death during the pandemic, driven by an intense innate immune response…
- Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations · 51 min · Temporada 5 Episódio 1Five years ago, The Stem Cell Report set out with a simple goal: to bring the science, the people, and the stories behind stem cell research into one conversation. Since then…
- Making Sense of Touch · 46 min · Temporada 4 Episódio 11Our guests today created new lab models to study Merkel cells using mouse whisker tissue cultures, mouse skin organoids, and human skin organoids. These models allowed them to…
- Illuminating hPSC-derived Sensory Neurons · 35 min · Temporada 4 Episódio 10Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that were…
- Tuning the X · 43 min · Temporada 4 Episódio 9Epigenetic regulation of gene expression is an important mechanism in development and disease. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications for…
- Building a Better Barrier: Modeling the Human Gut Epithelium · 43 min · Temporada 4 Episódio 8The human intestinal epithelial barrier comprises diverse proliferative, secretory and absorptive cell types that facilitate nutrient digestion and absorption and protect against…
- Crossing the Border: Modeling the Blood Brain Barrier · 30 min · Temporada 4 Episódio 7The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins…
- Movin’ On Out: Mobilizing HSCs From The Bone Marrow · 33 min · Temporada 4 Episódio 6Hematopoietic stem cells (HSCs) normally reside in the bone marrow niche but can traffic across the bone marrow endothelium into the bloodstream to populate different niches…
- Cancer Neuroscience, Tumor Organoids, and Understanding the Role of the Nervous System in Human Glioblastoma · 46 min · Temporada 4 Episódio 5The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and…
- Stem Cells in Space: Muscle Regeneration in Microgravity · 40 min · Temporada 4 Episódio 4Skeletal muscle is one of the most abundant tissues in the human body, representing approximately 40% of body weight. Under certain circumstances, skeletal muscle can be…
- Parkinson's Disease, Cell Therapy, and Exercise · 39 min · Temporada 4 Episódio 3The potential of pluripotent stem cells and the ability to scale and differentiate them to generate large numbers of enriched cell populations has created new opportunities and…
- Leaving an Imprint: The Function, Impact, and Detection of Epigenetic Marks · 54 min · Temporada 4 Episódio 2Parent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and…
- Don’t Dull the SPARCL: The Lung Microvasculature and its Role in Development · 43 min · Temporada 4 Episódio 1The mature lung in both humans and mice is highly vascularized, with approximately 30% of all cells being endothelial cells (ECs). The blood vessels have a physiological role in…
- A Look Into the Future of Stem Cell Reports: A Conversation with Janet Rossant · 58 min · Temporada 3 Episódio 14In this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what she sees…
- SeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality Assessment · 34 min · Temporada 3 Episódio 13During the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological…
- Guidelines for Managing and Using the Digital Phenotypes of Pluripotent Stem Cell Lines · 54 min · Temporada 3 Episódio 12The ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development and…
- PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development · 43 min · Temporada 3 Episódio 11Pluripotent stem cells are defined, in part, by their potential to generate cell types from all three embryonic germ layers. However, it is well known within the field that there…
