Behind the Breakthroughs
by Inside Precision Medicine
Latest episode
Ryan Beal: Getting Under Cancer's Skin
Ryan Beal: Getting Under Cancer's Skin
About this podcast
Medicine is full of breakthroughs. Most don't become medicine. Behind the Breakthroughs explores scientific ideas that could change how we diagnose and treat disease—and what it will take for them to work. Host Jonathan D. Grinstein, PhD, a scientist-turned-journalist, speaks with the researchers, physicians, and entrepreneurs building the next generation of genetic medicines, diagnostics, AI, precision therapeutics, and biotechnology. Hosted on Acast. See acast.com/privacy for more information.
Episodes
The newest 20 of 54 episodes
- Ryan Beal: Getting Under Cancer's Skin · 52 min · Episode 54Dyve Biosciences is developing a technology to deliver drugs through the skin that conventional transdermal approaches cannot accommodate. Its lead oncology program, DV800…
- Hussam Al Kateb: Inside Mayo Clinic’s Genomic Diagnostics Revolution · 41 min · Episode 53Mayo Clinic Laboratories’ new whole-transcriptome RNA sequencing assay expands the detection of clinically significant gene fusions across solid tumors, helping refine cancer…
- Matt Begemann: The Cancer-Killing CRISPR · 46 min · Episode 52What began as a search for plant-friendly CRISPR tools led Matt Begemann, PhD, and colleagues to Cas12a2, or CasCLEAR, an unusual system that can trigger broad nucleic acid…
- Wei-Wu He: Craig Venter’s Legacy and the Future of Human Longevity · 1 h 2 min · Episode 51Human Longevity executive chairman Wei-Wu He discusses how the integration of genomics, advanced imaging, and artificial intelligence could transform disease prediction and…
- Palani Kumaresan: Roche Diagnostics Is Ramping Up—Should Illumina Be Worried? · 59 min · Episode 50Roche’s AXELIOS sequencer, Alzheimer’s blood test, and push to automate mass spectrometry point to a broader strategy of making advanced diagnostics routine. Whether AXELIOS can…
- Ken Greenberg: Can Ultrasound Shatter the Gene Therapy Delivery Bottleneck? · 52 min · Episode 49Gene therapy’s biggest bottleneck remains delivery: getting increasingly sophisticated genetic medicines safely into the right cells. SonoThera is taking a radically different…
- David Thaisrivongs: Goldilocks and the First Oral PCSK9 Inhibitor · 42 min · Episode 48Biocatalysis has evolved from a scientific curiosity into a powerful manufacturing platform, culminating in enlicitide, the first oral macrocyclic peptide PCSK9 inhibitor…
- Beaubrun and Acharya: No Antibiotic Without a Diagnostic · 57 min · Episode 47Antimicrobial resistance (AMR) isn't going to be solved by new antibiotics alone—it also requires identifying resistant infections quickly enough to guide treatment and prevent…
- Amit Etkin: Precision Psychiatry’s Future Isn’t Genomics—It’s Brain Activity · 1 h 0 min · Episode 46For decades, psychiatry has relied on symptom-based diagnosis and trial-and-error treatment, but precision medicine is set to transform mental health care by using objective…
- Michael Antonov: From Virtual World Builder to Real-World Drug Designer · 1 h 2 min · Episode 45AI is transforming biomedical research, but meaningful advances in drug discovery require more than just increasingly powerful algorithms—they depend on combining machine…
- Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders · 59 min · Episode 44Philippe Pouletty, MD, is one of Europe’s most successful life sciences entrepreneurs, having spent more than 30 years building category-leading biotechnology and medical…
- Arthur Caplan: The Right to Life, Liberty, and Pursuit of Health · 1 h 0 min · Episode 43While growing up during the polio era, Arthur Caplan, PhD, saw doctors hide painful truths from families and children, which sparked his lifelong questions about power…
- Carolina Aguilar: Brain-Computer Interfaces that Heal Neural Circuits · 55 min · Episode 42Brain-computer interfaces have gained widespread attention largely for assistive applications, but Carolina Aguilar sees their greatest potential in directly treating…
- Matthew Rabinowitz: Engineering a New Era of Diagnosis · 1 h 7 min · Episode 41Matthew Rabinowitz, PhD, moved from engineering to medicine after his Human Genome Project work, motivated by both scientific insight and personal loss that exposed the limits of…
- Jurgi Camblong: Data-Driven Doctors Without Borders · 1 h 0 min · Episode 40Precision medicine promises individualized care through data, but progress remains fragmented. Clinical, genomic, and imaging data are siloed, limiting real-world use. Jurgi…
- Molly Gibson: Superintelligence and the Future of Drug Development · 51 min · Episode 39As an Origination Partner at Flagship Pioneering, Molly Gibson, PhD, co-founded her first company, Generate:Biomedicines, in 2018, where she made her mark by developing models…
- Mike Curtis: Pig Organs as a Bridge to Human Transplants · 52 min · Episode 38Xenotransplantation has long been a scientifically promising but ethically complex field, overshadowed by its limited practicality despite the growing shortage of transplantable…
- Markus Warmuth: Eliminating Pathogenic Proteins with Molecular Glue Degraders · 48 min · Episode 37Traditional drugs usually inhibit specific protein sites, but many disease-causing proteins lack accessible or unique motifs, leaving them “undruggable.” Targeted Small-molecule…
- Alicia Zhou: The Dark Matter for Cancer Immunotherapy Translation · 57 min · Episode 36Cancer Research Institute CEO Alicia Zhou, PhD, traces her path from teenage lab technician to leader in cancer immunotherapy. Trained at MIT and Dana-Farber, she worked on The…
- Brad Ringeisen: CRISPR for Disease Elimination and Humanitarian Solutions · 58 min · Episode 35CRISPR has crossed a turning point, evolving from an experimental tool into a platform delivering FDA-approved therapies and on-demand patient treatments that correct disease at…
