Neural Compass
by Jimini Health
Your Brain Learns Fear Every Time You Avoid It
About this podcast
If you work in mental health, invest in it, build in it, or just believe it deserves better than it is getting: Neural Compass is for you.
Filter episodes by category to find exactly what you're looking for, from AI Meets the Clinic to Founders & Funders to Behavioral Science, right here: https://jiminihealth.com/podcast
Every two weeks, Jimini Health co-founder Mark Jacobstein sits down with the scientists, clinicians, and executives who are actually moving the field. The conversations go deep. The guests are the real thing.
Episodes have covered the clinical case for ketamine, the genomics of psychiatric diagnosis, what AI can and cannot do for behavioral health, and what it takes to reform mental healthcare from inside the system.
Guests have included former National Institute of Mental Health director Tom Insel, Yale psychiatry chair John Krystal, and researchers and executives at the frontier of behavioral health and AI.
Episodes
The newest 20 of 32 episodes
- Your Brain Learns Fear Every Time You Avoid It · 40 min · Season 3 Episode 9Avoidance works remarkably well in the short term: it lowers discomfort almost immediately. The problem is that every escape teaches the brain that the thing you avoided was…
- Trauma Is Inherited But So Is Resilience · 41 min · Season 3 Episode 8Resilience acts as a physical shield that protects babies from inheriting family trauma during their first 2,000 days of life. This discovery helps us build the practical…
- Repetition Doesn’t Make You Learn Faster, Spacing Does · 39 min · Season 3 Episode 7The number of repetitions has zero influence on overall learning when spaced out over a fixed period. This gap in our scientific understanding has limited how we design…
- Your Brain Hates Unpredictability · 56 min · Season 3 Episode 6Psychedelics may increase apparent disorder in the brain, but beneath that disorder, Adeel Razi’s research found structured brain trajectories shaped by the quality and context…
- Your Immune System Might Be Causing Your Depression · 36 min · Season 3 Episode 5Think about the last time you were really sick. You didn't want to eat, you stayed in bed, you lost interest in everything. That's your immune system talking to your brain. For…
- America Prescribed Its Way Into An Epidemic · 36 min · Season 3 Episode 4Have you ever thought about the way medicine supplies are managed? Changing a computer default setting can stop a patient from getting a month-long supply they do not need. Small…
- Overdose Deaths Just Had Their Biggest Drop In History, with Keith Humphreys, Stanford Professor · 42 min · Season 3 Episode 3Overdose deaths dropped 27% in a single year, the largest decline ever recorded. Most people have no idea it happened. Keith Humphreys, Stanford addiction expert and adviser to…
- Healthcare was designed to fail, with Andy Slavitt · 40 min · Season 3 Episode 2People are already going to ChatGPT as their doctor. Not occasionally, habitually. Andy Slavitt ran Medicare and Medicaid under Obama, helped rescue healthcare.gov, and now…
- The Science Advanced. The Patients Did Not Get Better, with Dr. Thomas Insel · 39 min · Season 3 Episode 1The National Institute of Mental Health funded 900 new research grants by this point last year. This year: 109. That gap is bigger than a budget number. Tom Insel ran that…
- The Measuring Gap: How AI and objective data are finally transforming psychiatric care, with Arpan & Amit Parikh · 47 min · Episode 13You’ve likely heard that psychiatric progress is often stalled by subjective results. What is less understood is why the field remains slow to adopt in objective measurement even…
- Why Your Brain Functions Like a Specialized Swiss Army Knife, with Michael Platt · 50 min · Episode 12Neuroeconomics, leadership, and brain health are essential for modern performance. Professor Michael Platt from UPenn explains why digital glass creates cognitive exhaustion. You…
- Why Healthcare, Ever the Tech Laggard, Finally Got the AI Memo, with Jacob Effron · 37 min · Episode 11What if healthcare’s biggest AI breakthroughs aren’t about new science—but about finally fixing systems that were never built to scale?In this episode of Neural Compass, Jacob…
- Talking “Conversational Doorknobs” & Broken Science with the Funniest Man in Psychology, Adam Mastroianni · 46 min · Episode 10What if the hardest problems in psychology aren’t about data or statistics—but about how we talk, think, and decide what counts as truth?In this episode of Neural Compass…
- Tech, AI, and the Future of Therapy, with Dr. Harry Ritter, Alma's CEO · 40 min · Episode 9What if fixing mental healthcare isn’t about replacing clinicians—but finally giving them the systems they’ve always lacked?In this episode of Neural Compass, Dr. Harry Ritter…
- Can Stress Rewire the Brain—Across a Lifetime? with Dr. Nikolaos Daskalakis · 42 min · Episode 8Why do some people emerge from trauma resilient, while others carry its effects for decades—or even generations?In this episode of Neural Compass, Harvard neuroscientist and…
- Can DNA Data Unlock the Next Era of Medicine? with Dr. Yaniv Erlich · 51 min · Episode 7What if the answers to mental health, aging, and disease have been encoded inside us all along?In this episode of Neural Compass, geneticist and entrepreneur Dr. Yaniv Erlich…
- Is this the "Century of the Brain"? with Greg Kubin & Matias Serebrinsky · 44 min · Episode 6What if the next breakthrough in mental health isn’t a molecule—but a mindset?In this episode of Neural Compass, PsyMed Ventures co-founders Greg Kubin and Matias Serebrinsky…
- Are We Teaching AI to Care—or Just to Sound Like It? with Dr. Nick Haber · 42 min · Episode 5What happens when the tools we build to understand us start to change what it means to be human?In this episode of Neural Compass, Stanford’s Dr. Nick Haber—computer scientist…
- What Does It Take To Reform Mental Health Care From The Inside Out? with Mike Kopko · 39 min · Episode 4In this episode of Neural Compass, Mike Kopko—CEO and co-founder of Pearl Health—joins Jimini’s Mark Jacobstein to explore how value-based care, provider enablement, and…
- How Do We Deliver Better Mental Health Care At Scale? with Dr. Stephanie Eken · 42 min · Episode 2What does it actually take to deliver high-quality behavioral health care to hundreds of thousands of people?In this episode of Neural Compass, Dr. Stephanie Eken—Chief Medical…







