The Human Upgrade: Biohacking for Longevity & Performance
by Dave Asprey
Latest episode
Immortal Jellyfish, Fructose & Cancer, Cleaner Air for Blood Sugar…
Immortal Jellyfish, Fructose & Cancer, Cleaner Air for Blood Sugar…
About this podcast
For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.
Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.
This isn’t just self-improvement - it’s human enhancement backed by data.
Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.
Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
Episodes
The newest 50 of 1,626 episodes
- Immortal Jellyfish, Fructose & Cancer, Cleaner Air for Blood Sugar, Carbon Dioxide for Alzheimer's, and More : 1573 · 11 min · Episode 1573Host Dave Asprey explores five surprising health discoveries involving carbon dioxide and brain waste clearance, cleaner air and blood sugar, an immortal jellyfish's age-reversal…
- The Hidden Health Warnings in Your Poop (And Why You Should Look) | Chloe Melas : 1572 · 1 h 7 min · Episode 1572Chloe Melas joins Dave Asprey to share her 15-year journey with ulcerative colitis and discuss gut health, chronic inflammation, the role of diet and lifestyle, and breaking the…
- Why Your Brain Craves Things That Make You Miserable | Luke Storey : 1571 · 1 h 6 min · Episode 1571Luke Storey joins Dave Asprey to explore his journey from addiction and childhood trauma to sobriety and spiritual connection, discussing how psychedelics, biohacking, and the…
- 15 Minutes Every Morning Kills Insulin Belly Fast : 1570 · 17 min · Episode 1570I need a You'll learn section for this episode, similar to the format of this example: You'll Learn: Why modafinil is considered the closest thing to a "Limitless pill" and how…
- Brain-Cleaning Beds, Forever Chemicals, Peptide Freedom, Coffee for Your Heart, and More : 1568 · 10 min · Episode 1568Dave Asprey breaks down new research on brain waste clearance, taurine and inflammation, removing forever chemicals through plasma donation, expanded access to experimental…
- How to Get Really Good at Anything: The 3 Ingredients of Mastery | Roman Tsunder : 1569 · 59 min · Episode 1569Dave Asprey sits down with Roman Tsunder to explore the psychology of high achievement, the power of obsession and focus, overcoming fear and failure, and how to pursue…
- The Truth About Vitamins, Supplements & Prescription Drugs | Phil Cowley : 1567 · 1 h 7 min · Episode 1567Dave Asprey sits down with a compounding pharmacy expert to explore how pharmaceutical companies profit from nature-inspired medicines, why personalized treatments are gaining…
- I Tried EVERY Controversial Focus Drug : 1566 · 38 min · Episode 1566Dave Asprey shares what he learned testing every controversial and banned focus drug over 25 years, ranking modafinil and racetams as the best performers while crowning…
- Placebo Pills, Cannabis, Wall Squats for Blood Pressure, Birdwatching, and the Porn brain : 1564 · 11 min · Episode 1564Dave Asprey explores how placebo pills can relieve symptoms even when patients know they're fake, how wall squats can lower blood pressure, why birdwatching may benefit brain…
- The No-Brainer Solution To Stop Overeating : 1565 · 52 min · Episode 1565Dave Asprey sits down with Calocurb CEO Sarah Kennedy to explore how bitter hops compounds stimulate natural GLP-1 and other satiety hormones to reduce appetite, support weight…
- The Easiest Treatment That Made Me 15 Years Younger : 1563 · 43 min · Episode 1563Dave Asprey and Dr. Tim Cook explore experimental gene therapies, stem cell re-education, and emerging longevity technologies that could reverse biological aging, rejuvenate the…
- How To Reverse Your Age For $5 Day (Budget Biohacking) : 1562 · 24 min · Episode 1562Dave Asprey reveals how to build a science-backed longevity routine for less than $5 a day using affordable supplements, better sleep, sunlight, walking, and simple habits that…
- Avoid THESE "Healthy" Superfoods : 1561 · 1 h 15 min · Episode 1561Dave Asprey and integrative practitioner Terry Cochran discuss how four metabolic disruptors — amyloids, oxalates, sulfur malabsorption, and histamine — are hijacked by…
- How to Trigger Flow States From The 5 Brain Chemicals You Need : 1559 · 56 min · Episode 1559Dave Asprey and Steven Kotler explore the neuroscience of flow states, psychedelics, brain chemistry, trauma, consciousness, and how to train your brain for peak performance…
- The 6-Minute Morning Routine That Can Change Your Life : 1558 · 49 min · Episode 1558Dave Asprey and Hal Elrod explore how morning routines, visualization, affirmations, meditation, and the six SAVERS habits can help reprogram your mindset, overcome…
- 400mg Before Bed Improves Deep Sleep by 1700% : 1557 · 13 min · Episode 1557I slept 8 hours a night and got 5 minutes of deep sleep, and no doctor could help me.
- John Gray: Why Men Stop Wanting Their Wives : 1556 · 1 h 45 min · Episode 1556John Gray explains how testosterone and estrogen drive male-female relationship dynamics, from emotional communication and conflict resolution to sexual polarity and recovering…
- Sleep Expert: 80% of Sleep Problems Come From THIS : 1555 · 40 min · Episode 1555Sleep expert Dr. Michael Breus joins Dave Asprey to reveal why fear and anxiety may be driving your sleep problems, how chronotypes and circadian rhythms affect sleep quality…
- The Science Behind Joint and Cartilidge Repair : 1554 · 49 min · Episode 1554Host Dave Asprey sits down with research microbiologist Kiran Krishnan to explore groundbreaking research on cartilage regeneration, joint repair, nitric oxide, vascular health…
- Your Brain Has a Focus Switch (Here's How to Turn It On) : 1553 · 19 min · Episode 1553Your focus depends on a norepinephrine and dopamine "switch" that chronic stress, bad sleep, and sitting all day drain, and you can turn it back on in about 20 minutes with…
- Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552 · 11 min · Episode 1552Dave Asprey breaks down five new health stories on infection-driven cancer risk, finasteride side effects, blueberries and polyphenols, vitamin D and male fertility, and why…
- How to Unlock Psychic Abilities to Know When You’ll Die : 1551 · 1 h 4 min · Episode 1551Dave Asprey and psychic medical intuitive Julie Ryan explore whether intuitive abilities can be trained, how they may relate to healing and consciousness, and what Julie says…
- How to Live Healthier Without Obsessing Over Health : 1550 · 52 min · Episode 1550Miranda Kerr joins Dave Asprey to explore how simplifying health around clean living, sleep, stress management, meditation, family, and intentional skincare can create a more…
- It's Boring, But It Slashed ALL My Visceral Fat In My 50s : 1549 · 19 min · Episode 1549Dave Asprey shares the five hacks that helped him lose over 100 pounds and feel decades younger, from inventing butter coffee in Tibet to eating more saturated fat, cutting…
- Vagus Nerve Memory, Cat Cancer Genes, Inherited Intelligence, Mulberry Microbes, and Vitamin D : 1548 · 11 min · Episode 1548Dave Asprey breaks down new research on vagus nerve stimulation and memory, feline cancer genetics, inherited cognitive ability, mulberries and the microbiome, and how magnesium…
- Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547 · 47 min · Episode 1547The founders of Young Goose explore science-backed, longevity-focused skincare — covering metabolomic skin testing, key ingredients like ergothioneine and ectoin, mitochondrial…
- The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk : 1546 · 57 min · Episode 1546Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & Longevity
- Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545 · 14 min · Episode 1545Dave Asprey outlines six science-backed methods to melt visceral fat—ranging from high-protein eating and HIIT to cold exposure, weightlifting, quality sleep, and stress…
- Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544 · 15 min · Episode 1544A roundup of five health stories — Novo Nordisk's interest in hair loss, nutritional deficiencies in kids on GLP-1s, stomach-brain synchronization and mental health, food…
- The Best Singular Hack To Change EVERYTHING About Your Life : 1543 · 1 h 13 min · Episode 1543Dr. Robert Waldinger shares findings from the 85-year Harvard Study of Adult Development revealing that the quality of our relationships—not wealth, fame, or power—is the single…
- 15g Every Morning for Anti-Aging Mitochondria : 1541 · 59 min · Episode 1541Dave Asprey and Catharine Arnston explore how spirulina and chlorella may support mitochondrial function, cellular energy, detoxification, brain health, and healthy aging.
- I Wasted 10 Years Stuck With Brain Fog Until I Learned This : 1540 · 21 min · Episode 1540A mold illness survivor explains how toxic mold in your home and body causes chronic brain fog, fatigue, and inflammation — and lays out a step-by-step plan to identify the…
- Teal Swan - Beyond the Veil of Ego, AI & Wisdom : 1539 · 1 h 2 min · Episode 1539Dave Asprey sits down with spiritual teacher Teal Swan to explore narcissism, betrayal, extrasensory perception, the nature of ego, divine masculine and feminine energy, and…
- How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538 · 54 min · Episode 1538Dave Asprey and neurobiologist Dr. Michael Leon explore how your sense of smell influences memory, sleep, brain aging, and longevity, and why olfactory enrichment may be one of…
- Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537 · 56 min · Episode 1537This episode is a wide-ranging conversation covering testosterone and hormone replacement therapy, peptides, biohacking, psychedelics and spirituality, parenting, and building a…
- The Peptide Secrets to a Youthful Face : 1536 · 56 min · Episode 1536Dave Asprey and Carolina Reis de Oliveira break down how senescent cells, menopause, hydration loss, and peptide science affect skin aging, and what the latest research suggests…
- What 36 Hours Without Sugar Does to Your Body : 1535 · 12 min · Episode 1535This episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning…
- New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534 · 10 min · Episode 1534This week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an…
- Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533 · 1 h 9 min · Episode 1533Dave Asprey and Dr. Karan Rajan dive deep into gut health, covering fiber science, fermentation, sodium myths, and the weirdest things a GI surgeon has ever removed from a patient.
- If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532 · 10 min · Episode 1532Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin…
- Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531 · 8 min · Episode 1531This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to…
- Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530 · 1 h 58 min · Episode 1530Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed…
- 3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529 · 36 min · Episode 1529Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone…
- 7 Brain Compounds I Take For Superhuman Focus : 1528 · 10 min · Episode 1528can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real…
- Change Your Morning, Change Your Life! Hal Elrod : 1527 · 1 h 13 min · Episode 1527Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak…
- Learn THIS And You’ll Become Impossible To Trigger : 1526 · 1 h 1 min · Episode 1526Jonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and…
- Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525 · 1 h 1 min · Episode 1525Jim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.
- The Most Important Longevity Molecule I've Ever Found : 1524 · 15 min · Episode 1524Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.
- The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523 · 36 min · Episode 1523Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using…
- The Wild New Theory of Cancer (It's GOOD For You?) : 1522 · 1 h 3 min · Episode 1522Patrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that…
