QCast: Data-Driven Dialogue in Drug Development
af Quanticate
Seneste episode
Episode 70: Clinical Trial Planning and Design
Episode 70: Clinical Trial Planning and Design
Om denne podcast
QCast by Quanticate is the podcast for biotech, pharma, and life science leaders looking to deepen their understanding of biometrics and modern drug development. Join co-hosts Tom and Jullia as they explore methodologies, case studies, regulatory shifts, and industry trends shaping the future of clinical research. Where biometric expertise meets data-driven dialogue, QCast delivers practical insights and thought leadership to inform your next breakthrough.
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- Episode 70: Clinical Trial Planning and Design · 11 min. · Episode 70Clinical trial design decisions can have consequences across the protocol, analysis and delivery of a study. In this QCast episode, co-hosts Jullia and Tom examine how a clear…
- Episode 69: SDTM Mapping Automation Tool · 11 min. · Episode 69In this QCast episode, co-hosts Jullia and Tom examine how SDTM mapping automation tools use approved rules and metadata to generate mapping specifications and SAS code, and…
- Episode 68: AI in Clinical Trial Design · 11 min. · Episode 68AI and machine learning can help research teams make more informed clinical trial design decisions, from assessing protocol feasibility to identifying suitable patient…
- Episode 67: The Analysis of Direct and Indirect Pathways in Observational Studies · 12 min. · Episode 67In this episode, Jullia and Tom discuss direct and indirect pathways in observational studies, with a focus on mediation analysis and what it can, and cannot, show. Using an…
- Episode 66: What is Clinical Traceability? · 12 min. · Episode 66Clinical traceability is about being able to follow evidence from a reported result back to its source and understand the transformations, decisions, and records in between. In…
- Episode 65: Clinical Trial Trends Shaping Modern Drug Development · 12 min. · Episode 65Clinical trial trends matter most when they affect how studies are designed, delivered, and overseen. In this QCast episode, co-hosts Jullia and Tom discuss how decentralised…
- Episode 64: Tipping Point Analysis in Clinical Trials · 10 min. · Episode 64Tipping point analysis helps trial teams understand how strongly a study conclusion depends on assumptions about missing data. In this QCast episode, co-hosts Jullia and Tom…
- Episode 63: Audit Trail Review in Clinical Trials · 10 min. · Episode 63Audit trail review can involve far more than checking whether a system records changes. In this QCast episode, co-hosts Jullia and Tom discuss how trial teams can decide what…
- Episode 62: Drug Adherence and Persistence · 11 min. · Episode 62Drug adherence and persistence measures built from claims or EHR databases depend as much on study definitions as recorded treatment events. In this QCast episode, co-hosts…
- Episode 61: The Role of Data Monitoring Committees (DMC) in Clinical Trials · 12 min. · Episode 61In this QCast episode, Jullia and Tom discuss the role of data monitoring committees, or DMCs, in clinical trials. They explain how DMCs support participant safety and trial…
- Episode 60: Oncology Phase 1 Trial Design · 11 min. · Episode 60In this QCast episode, Jullia and Tom discuss how oncology Phase 1 trial design has moved beyond simply identifying the maximum tolerated dose. They look at dose optimisation…
- Episode 59: Clinical Data Quality · 11 min. · Episode 59In this QCast episode, Jullia and Tom look at how clinical data quality is shaped from study set-up through collection, review and integration. They discuss why clear…
- Episode 58: Rescue Studies · 10 min. · Episode 58In this QCast episode, Jullia and Tom discuss how sponsors can assess a study in difficulty, decide how to handle existing databases and data, manage handovers, and set realistic…
- Episode 57: Clinical Trial Performance Metrics · 9 min. · Episode 57In this QCast episode, Jullia and Tom examine how clinical trial performance metrics can support better oversight without creating unnecessary reporting burden. They explain the…
- Episode 56: Bayesian Clinical Trial Design · 10 min. · Episode 56In this QCast episode, co-hosts Jullia and Tom explain how priors, posterior probabilities and predictive probabilities support clinical decisions. They also discuss external…
- Episode 55: What is Adaptive Trial Design? · 10 min. · Episode 55In this QCast episode, Jullia and Tom examine how adaptive trial design allows pre-specified changes to a clinical trial using accumulating interim data. They look at common…
- Episode 54: SAS vs R vs Python in Clinical Trials · 12 min. · Episode 54In this QCast episode, Jullia and Tom look at SAS vs R vs Python through the lens of clinical trial delivery. Rather than treating the choice as a programming preference, they…
- Episode 53: Decentralised Clinical Trials · 11 min. · Episode 53In this QCast episode, Jullia and Tom discuss decentralised clinical trials and what they mean for clinical development teams in practice. The episode looks at decentralisation…
- Episode 52: The Global Statistical Test for Multiple Endpoint Analysis · 10 min. · Episode 52In this QCast episode, Jullia and Tom discuss the Global Statistical Test for multiple endpoints analysis and why it can be useful when a clinical trial needs to assess more than…
- Episode 51: CDASH Standards and Conformance in Clinical Data Management · 10 min. · Episode 51In this QCast episode, Jullia and Tom discuss CDASH standards and conformance in clinical data management, with a focus on where CDASH sits in the clinical data flow and why it…
