Longevity Roadmap
by Buck Joffrey
Latest episode
169: Protein Folding Errors Contribute to Aging and Disease
169: Protein Folding Errors Contribute to Aging and Disease
About this podcast
Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.
Episodes
The newest 20 of 171 episodes
- 169: Protein Folding Errors Contribute to Aging and Disease · 29 minIn this episode, we are joined by Dr. Judith Frydman to explore proteostasis: the tightly regulated systems that ensure proteins are correctly folded, maintained, and cleared…
- 168: Best of 2025 · 23 minOver the past year, we covered a wide range of ground—from clinicians working directly with patients to top scientists studying the underlying biology of aging. This episode is a…
- 167: Why Bats Don't Age and Why You Should Care with Dr. Emma Teeling · 37 minAging is usually linked to size, metabolism, and inevitable decline—but bats defy all three. In this episode, Dr. Buck Joffrey speaks with Dr. Emma Teeling about why bats are…
- 166: BioXcellerator - The Cutting Edge of Stem Cell Therapy · 46 minLongevity medicine is moving beyond symptom management—and regenerative therapies are forcing a deeper look at how healing actually works. In this episode, Dr. Buck Joffrey…
- 165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo · 35 minAging begins when cellular quality-control systems lose their precision. In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective…
- 164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray · 34 minIn this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging. He explains how systemic factors, particularly…
- 163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima · 59 minIn this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline. He begins by outlining how…
- 162: The Habits of Healthy Aging with Dr. Kate Wolin · 25 minWe are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real…
- 161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff · 30 minIn this episode, we are joined by Dr. Jennifer Elisseeff to discuss the evolving field of tissue engineering and its applications in regenerative medicine. She explains the shift…
- 160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum · 33 minDr. Heidi Tissenbaum, a molecular geneticist at UMass Chan Medical School, joins Dr. Buck Joffrey to explore what C. elegans worms have revealed about the biology of aging. She…
- 159: How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg · 33 minThis week, Professor Jan Vijg joins us to discuss the intricate relationship between DNA mutations, epigenetic drift, and aging. He explains the differences between mutations and…
- 158: Sitting Is the New Smoking with Dr. Keith Diaz · 25 minIn this episode, we are joined by Dr. Keith Diaz to discuss the significant health risks associated with prolonged sitting, likening it to smoking in terms of its dangers. He…
- 157: The Role of Surgery in Diabetes and Obesity with Dr. Mitchell Roslin · 41 minIn this episode, we are joined by Dr. Mitchell Roslin to discuss the complexities of obesity. We explore the role of GLP-1 medications in weight management, the evolution of…
- 156: Investing in the Business of Aging with Dr. Karl Pfleger · 32 minIn this episode, Dr. Karl Pfleger joins us to discuss the evolving landscape of longevity research and investment. He emphasizes the shift from disease-specific approaches to…
- 155: Can Psilocybin Extend Cellular Lifespan? with Dr. Louise Hecker · 28 minIn this episode, Dr. Louise Hecker joins us to discuss her groundbreaking research on psilocybin, exploring its potential to extend cellular lifespan and improve health outcomes…
- 154: Is Telomere Length Shortening the Master Switch of Aging? with Dr. Bill Andrews · 48 minIn this episode, Dr. Bill Andrews joins Dr. Buck Joffrey to discuss the critical role of telomeres and telomerase in aging and cellular health. He explains how telomeres shorten…
- 153: T Cells, Aging, and Extreme Life Extension with Dr. Derya Unutmaz · 50 minDr. Derya Unutmaz joins Dr. Buck Joffrey to discuss the critical role of T cells in the immune system, their changes with aging, and the implications for chronic diseases. He…
- 152: The Role of Vitamin A in Brain Health with Prof. Peter McCaffery · 37 minIn this episode, Professor Peter McCaffery joins Dr. Buck Joffrey to discuss the multifaceted role of Vitamin A in brain health, particularly its function as a signaling molecule…
- 151: Does Astaxanthin Increase Longevity? with Dave Watumull · 42 minIn this episode, Dave Watumull joins Dr. Buck Joffrey to discuss the benefits and mechanisms of astaxanthin, a powerful antioxidant and anti-inflammatory compound. He explains…
- 150: The Microbiome's Role in Aging and Healthspan with Dr. Sean Gibbons · 40 minDr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our…
